The Tutorials in Biostatistics series has become a very popular feature of the journal, Statistics in Medicine. The tutorials are accessible, self-contained and of a uniformly high quality. This book represents the first of two volumes presenting the best tutorials published in the journal, focusing on statistical methods in clinical studies. Topics include the design and analysis of clinical trials, epidemiology, survival analysis, and data monitoring. Each tutorial has been fully peer-reviewed and edited, and authored by leading researchers in biostatistics. Presents a collection of tutorials in biostatistics, taken from the prestigious Wiley journal, Statistics in Medicine. Focuses on methods in clinical studies, including epidemiology, survival analysis, design and analysis of clinical trials, and data monitoring. Each tutorial has been fully peer reviewed and edited to ensure a high level of quality and to maintain the practical focus. Suitable for medical practitioners with a good understanding of statistics. Each tutorial has been authored by leading researchers in the field. The Tutorials in Biostatistics volumes provide an authoritative and readable introduction to a wide range of topics suitable for statisticians working in medical research, as well as statistically-minded clinicians, biologists, epidemiologists, and geneticists. Graduate students of biostatistics will find they make excellent reference volumes to support their study.D'Agostino, Ralph B. is the author of 'Tutorials In Biostatistics Statistical Modelling Of Complex Medical Data', published 2004 under ISBN 9780470023655 and ISBN 0470023651.