Protein Crystallography in Drug Discovery

The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins often forms the basis for an entire drug development program. Protein structures suited for rational drug design are almost exclusively derived from crystallographic studies, and drug developers are relying heavily on the power of this method. Here, researchers from academia and from leading pharmaceutical companies present valuable first-hand information on how to obtain the desired protein structures and how to exploit crystallographic data for the drug discovery process. From the contents: Crystallography of important target classes such as kinases and proteases Structure-based design of protease inhibitors Structure-based design of kinase inhibitors The ribosome and the proteasome as drug targets Recent methodological advances in high-throughput crystallography and microcrystallization An indispensable companion for crystallographers involved in protein structure determination as well as drug developers following the structure-based approach.Babine, Robert E. is the author of 'Protein Crystallography in Drug Discovery', published 2004 under ISBN 9783527306787 and ISBN 3527306781.