Human Drug Metabolism An Introduction

Human Drug Metabolism: An Introduction provides an accessible introduction to human drug metabolism for those who already have some understanding of the life sciences. It focuses only on essential chemical detail and includes patient case histories to illustrate the clinical consequences of changes in drug metabolism and its impact on patient welfare. After underlining the relationship between efficacy, toxicity and drug concentration, the book then considers how metabolising systems operate and how they impact upon drug concentration, both under drug pressure and during inhibition. Factors affecting drug metabolism, such as genetic polymorphisms, age and diet are discussed and how metabolism can lead to toxicity is explained. The book concludes with the role of drug metabolism in the commercial development of therapeutic agents as well as the pharmacology of some illicit drugs. focuses on a conceptual understanding of drug metabolism takes a user-friendly approach to the chemical aspect of drug metabolism includes a wealth of diagrams and illustrations provides strategies for maximising examination performance Human Drug Metabolism: An Introduction will be an invaluable resource for students studying pharmacology, pharmacy, bio-molecular sciences, biochemistry, molecular biology, toxicology, dentistry and medicine in addition to healthcare professionals and postgraduates.Coleman, Michael D. is the author of 'Human Drug Metabolism An Introduction', published 2005 under ISBN 9780470863534 and ISBN 0470863536.