Genetically Modified Model Report on Toxicology and Carcinogeneticity Studies of Dichloroacetic Acid (CAS No. 79-43-6) in Genetically Modified (FVB Tb. ACV Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenecity Studies of Dichloroacetic

Dichloroacetic acid was nominated for study by the EPA because of its widespread occurrence in drinking water as a byproduct of water disinfection using chlorination. It was also nominated because dicholoroacetic acid is the most studied representative of the class of haloacetic acids & has been shown to cause liver tumors in both rats & mice. Haloacetic acids are second only to trihalomethanes as a family of disinfection byproducts found in many drinking water supplies. Dichloroacetic acid is one of several disinfection byproducts being evaluated to determine whether genetically modified mouse models can serve as a more rapid & cost-effective means of evaluating & ranking potential hazards of disinfection byproducts. Illustrations.Boorman, G. A. is the author of 'Genetically Modified Model Report on Toxicology and Carcinogeneticity Studies of Dichloroacetic Acid (CAS No. 79-43-6) in Genetically Modified (FVB Tb. ACV Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenecity Studies of Dichloroacetic ', published 2007 under ISBN 9781422315200 and ISBN 1422315207.