Drug Metabolism in Pharmaceuticals: Concepts and Applications

Ala F. Nassar, Phd, provides technical and operational leadership in characterizing in vitro and in vivo metabolites. His research focuses on understanding how structure modification can improve the ADME profile for new chemical entities as they advance towards clinical candidacy. Recently, he identified and patented pharmacologically active metabolites of Nexavar. Dr. Nassar serves on the Editorial Board of Drug Metabolism Letters and The Open Drug Metabolism Journal and is also a reviewer for several other journals. Paul F. Hollenberg, Phd, is Maurice H. Seevers Collegiate Professor and Chair of Pharmacology at The University of Michigan. His current research focuses on the relationship between the structures of the active sites of cytochrome P450s and their catalytic function. Dr. Hollenberg was cofounder and Associate Editor of Chemical Research in Toxicology and has served on numerous editorial boards and review panels. Joann Scatina, Phd, has over twenty-four years of drug metabolism experience, and is currently Vice President of the Drug Metabolism Division, Drug, Safety and Metabolism, for Wyeth Research. Dr. Scatina's research interests include identification of metabolites, metabolic pathways and enzymes responsible, in vitro-in vivo extrapolation, and prediction of drug interactions. She is a member of the American Society for Pharmacology and Experimental Therapeutics and the International Society for the Study of Xenobiotics (ISSX) and is currently serving on the Editorial Board of Drug Metabolism Reviews.Nassar, Ala F. is the author of 'Drug Metabolism in Pharmaceuticals: Concepts and Applications', published 2009 under ISBN 9780470118030 and ISBN 0470118032.