Drug Etiology of Agranulocytosis and Aplactic Anemia

Agranulocytosis and aplastic anemia figure prominently among certain serious diseases which can be precipitated by drugs. Several hundred different agents with substantially different chemical and pharmacological properties have been implicated, although the evidence incriminating specific drugs has been largely anecdotal. This book describes the findings of a rigorous and comprehensive epidemiological investigation designed to provide reliable quantitative data on the drug etiology of agranulocytosis and aplastic anemia. This investigation was a large-scale, population based , case-control study. Its objectives were to identify those drugs associated with agranulocytosis and aplastic anemia, and to estimate incidence rates attributable to specific drugs. In both conceptual and practical terms, this study has broken new ground, by providing the most extensive documentation to date concerning the drug etiology and incidence of the two dyscrasias.Kaufman, David W. is the author of 'Drug Etiology of Agranulocytosis and Aplactic Anemia' with ISBN 9780195059830 and ISBN 0195059832.