Biomarkers & Risk Assessment

This book provides a guide to the concepts & principles governing the use of biomarkers to assess the risks to human health posed by exposure to chemical agents. Emphasis is placed on criteria for the selection & validation of appropriate biomarkers of exposure, of toxic effect, & of susceptibility in either individuals or sub-populations. The book also explains how the use of validated biomarkers to monitor exposed poulations can provide the basis for early public health interventions. The book opens with background information on the uses of biomarkers for health risk assessment, clinical diagnosis, & the monitoring of exposure, followed by a discussion of the principles & methods governing their selection & validation. The ethical & social issues that need to be considered when designing research projects are also discussed. The main part of the book sets out guidelines, supported by examples from recent research, for the selection & use of biomarkers of exposure, of effect, of carcinogenicity, & of susceptibility.WHO Staff is the author of 'Biomarkers & Risk Assessment ', published 1993 under ISBN 9789241571555 and ISBN 9241571551.