Advances in Pharmacology Cyclic Gmp Synthesis, Metabolism, and Function

Praise for the Serial "The book provides superb reading material which chemists and pharmacologists interested in the area of chemotherapy will surely enjoy reading." --JOURNAL OF PHARMACEUTICAL SCIENCES This volume is dedicated to the topic of cyclic GMP. Chapters include discussions on the guanylyl cyclase and phosphodiesterase isoenzyme families for cyclic GMP synthesis and hydrolysis, cyclic GMP-dependent protein kinases, and various hormones and ligands that regulate cyclic GMP formation and/or metabolism. Several chapters also deal with some of the effects of cyclic GMP on other second messangers such as calcium ion transport and smooth muscle relaxation. Some clinical studies with cyclic GMP and atrial natriuretic peptide are also discussed. The last chapter raises many important questions in the field that remain to be addressed. Key Features * Chapters discuss: * Isoforms of guanylyl cyclase and phosphodiesterase isoenzyme families for cyclic GMP synthesis and hydrolysis * Cyclic GMP-dependent protein kinase * Hormones and ligands that regulate GMP formation and/or metabolism * Effects of cyclic GMP on other second messengers and some functions such as smooth muscle relaxation and ion transport * Clinical studies with cyclic GMP and atrial natriuretic peptide * Important questions and experiments for the future Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, whether applied or experimental.August, J. Thomas is the author of 'Advances in Pharmacology Cyclic Gmp Synthesis, Metabolism, and Function' with ISBN 9780120329267 and ISBN 0120329263.